Profile

Abgentis

Abgentis’ goal is to provide a new broad-spectrum IV/oral antibacterial to treat acute and chronic, life-threatening and drug-resistant infections. Based on a previously marketed but uncompetitive compound, Abgentis’ “fast-follower” programme will deploy unique insight into the structure-activity relationships, microbiology, pharmacology and efficacy of antibacterial DNA supercoiling inhibitors to rapidly re-engineer and optimise, to create an internationally competitive product. The keys to market penetration are the IV and oral bioavailability (enabling step-down therapy), the spectrum of activity including both Gram+ve and Gram-ve pathogens and the ultra-low spontaneous resistance frequency.

Status current

Associated Fund Early Advantage Fund

Sector Medical / Biotechnology

Website www.abgentis.com/

Associated Team Members

Relevant News

Early Advantage Fund Invests £75,000 In Abgentis

A company creating new treatments for life-threatening and drug-resistant bacterial infections has received a cash…

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Abgentis’ Lead programme demonstrates efficacy against multi-drug resistant Gram-negatives

GYR12, Abgentis' lead novobiocin analogue, in combination with colistin, is effective against colistin-resistant strains...

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Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type...

Novel antibacterial programmes developed under the leadership of Lloyd Czaplewski when he was at...

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Lloyd Czaplewski speaks at Antibiotic Actions’ international conference

Antibiotic Action, supported by the BSAC, th Medical Research Council, The Wellcome Trust and...

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